Remodeling chromatin for senescence

Chromatin remodeling, BRCA1, SAHF and cellular senescence

Cellular senescence is a state of stable cell growth arrest. Activation of oncogenes in primary mammalian cells typically triggers cellular senescence. Oncogeneinduced senescence is an important tumor suppression mechanism, driving stable growth arrest of cancer progenitor cells harboring the initial oncogenic hit. Chromatin in the nuclei of senescent human cells is often reorganized to form sp...

Mechanism of chromatin remodeling.

Results from biochemical and structural studies of the RSC chromatin-remodeling complex prompt a proposal for the remodeling mechanism: RSC binding to the nucleosome releases the DNA from the histone surface and initiates DNA translocation (through one or a small number of DNA base pairs); ATP binding completes translocation, and ATP hydrolysis resets the system. Binding energy thus plays a cen...

SnapShot: Chromatin Remodeling: ISWI

SnapShot: Chromatin Remodeling Complexes

Unique subunits Swp82, Taf14, Snf6, Snf11 Rsc3,5,7,9, 10,30, Htl1, Ldb7, and Rtt102 INO80 regulates transcription and is involved in DNA repair and cellcycle checkpoint adaptation. It has ATP-dependent nucleosome mobilization activity in vitro. SWR1 regulates transcription and is also involved in deposition of histone H2AZ, chromosome stability, and cell-cycle checkpoint adaptation. In vitro it...

SnapShot: Chromatin Remodeling: CHD